11 results
Nephron Remodeling as a Mechanism of Diuretic Resistance. When high doses of loop diuretics are used
Nephron Remodeling ... basis, the distal nephron ... of the distal nephron ... Pathophysiology #Nephro ... #IM #LoopDiuretic
Mechanisms of Loop Diuretic Action and Resistance. Panel A, loop diuretics circulate bound to protein. As
Mechanisms of Loop Diuretic ... Panel A, loop diuretics ... shown in Panel C, diuretics ... Pathophysiology #Nephro ... #IM #LoopDiuretic
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... Metolazone Loop diuretics ... loss through the nephron ... loop #thiazide #classes
Hyperuricemia: Pathogenesis and Complications

 - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
arteriole in the nephron ... dose salicylates, diuretics ... tubule in the nephron ... blood into the nephron ... Release of purine bases
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... organic acids and bases ... acid and most diuretics ... vasopressin control #Nephron
Differential Diagnosis and Evaluation of Hyponatremia:
1) Identification of onset (acute vs. chronic)
2) Presence of symptoms (HA,
symptoms (HA, nausea ... Diagnosis #EM #IM #Nephro ... #Differential #Algorithm
Hyponatremia Diagnosis Algorithm
UOsm ≥ POsm - Vasopressin-Dependent
 • UNa < 20 mEq/L - Appropriate (↓ EABV)
Hyponatremia Diagnosis Algorithm ... Helbert Rondon, MD @NephroMD ... #differential #algorithm ... #causes #nephrology
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
reabsorption in the nephron ... kidney), which causes ... are similar to diuretics
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Causes of High-anion ... Metabolic Acidosis Causes ... and chronic) Causes ... Generalized distal nephron ... Potassium-sparing diuretics
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... cell/white cell casts ... Nephrocalcinosis causes ... nephron loss, causing ... #Algorithm #differential