7 results
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Metolazone Loop ... the collecting duct ... loss through the nephron ... the collecting duct ... #thiazide #classes
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... organic acids and bases ... acid and most diuretics ... Medullary collecting duct ... Segments #Function #Pathophysiology
Causes of Hypomagnesemia - Differential Diagnosis Algorithm
GI LOSS - FeMg < 2-2.5% or 24h Urine Mg
Causes of Hypomagnesemia ... Differential Diagnosis Algorithm ... Urine Mg > 10g • Loop ... • Cisplatin, Amp ... Magnesium #Low #Causes
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Causes of High-anion ... Causes of High-anion ... and chronic) Causes ... Distal (classic) ... differential #diagnosis #causes
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Differential Diagnosis Algorithm ... Remote use of loop ... or thiazide diuretics ... pressure: Active diuretic ... #causes #urinary
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Urinary Chloride Algorithm ... Remote use of loop ... or thiazide diuretics ... pressure: Active diuretic ... the indicated causes
Management of Hyponatremia
Hypertonic Saline - Only indicated if patient has severe symptoms + Na < 125
Give
(Max of 3 doses) ... Add Diuretics, Consider ... • IF SIADH — look ... for cause Reduced ... Hyponatremia #Management #algorithm