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diagnosis rheumatology lupus erythematosus syndrome table activation cancer cerebritis cns comparison differential diuresis diuretics druginduced emergencies excretion macrophage mas medications
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... • Early death Neutropenic ... Constipation • Nausea ... coma SIADH: • Hyponatremia ... • Nausea, vomiting
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Positive in 60-80% of cases ... life-threatening • Treatment ... #lupus #Systemic ... #Summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... 10,000 ng/mL • Hyponatremia ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Erythematosus (SLE ... autoantibodies that will cause ... cerebritis #diagnosis #management ... #treatment
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... months to years) Systemic ... life-threatening • Treatment ... Usual therapeutic management ... #diagnosis #management
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
irrigation • Management ... nephrotic syndrome • Hyponatremia ... Kidney stones caused ... Tolvaptan) • Treatment ... and euvolemic hyponatremia
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... DI Hematologic ... Adenocarcinoma Treatment ... #Diagnosis #Management
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