12 results
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
- Vasculitis, e.g ... - Vasculitis, e.g ... Celiac disease Anti-GBM ... diseases #diagnosis #table ... #rheumatology #
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome (GBS ... dissociation - Of note ... Electrodiagnostic studies (Ex EMG ... the underlying pathophysiology ... diagnosis #management #neurology
Main types of autoimmune encephalitis in the ICU. 
Anti-NMDAR anti-N-methyl-d-aspartate receptor, ADEM acute disseminated encephalomyelitis, Anti-GFAP
resonance imaging, EEG ... electroencephalography, Abs ... encephalitis #comparison #table ... #neurology #diagnosis
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
renal, lung, lymph node ... glands, lymph nodes ... Glucocorticoids (0.6 mg/kg ... maintenance with GCs ... workup #treatment #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... Lumbar Puncture, EEG ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Opsonization: Abs ... Neutralization: Abs ... storage sites (e.g ... . lymph nodes, spleen ... Humoral #Immunity #pathophysiology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
syndrome - SLE Neurologic ... disease, Vasculitis (e.g ... Heberden's nodes ... joints), Bouchard's nodes ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
affects the skin, neurologic ... Mucocutaneous lymph node ... cognitive impairment, neurologic ... pain and GN Anti-GBM ... Differential #Diagnosis #Rheumatology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... of diagnosis (e.g ... Self-limiting, chronic but stable ... peripheral lymph nodes
The Neurological Evaluation of a Comatose Patient

Definition:
 • Coma: a state of unresponsiveness; the absence of
• Mutism Pathophysiology ... • Carefully note ... Glasgow Coma Scale (GCS ... #PhysicalExam #neurology