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diagnosis differential causes cell endocrinology erythematosus extravascular fever function fuo hemolysis hemolytic hepatology hyperthyroidism intravascular laboratory lfts liver lupus macrocytic
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
FUO) - Further Workup ... Returning Traveler’ algorithm ... artery biopsy • Lab ... values supporting ... hematologic malignancies
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Algorithm Mean ... Normal range 11.5% ... Algorithm by Dr. ... #Workup #Hematology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Tests (LFTs) - Normal ... Values and Interpretation ... prothrombin time across labs ... #Interpretation ... #diagnosis #hepatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... mechanical cardiac valve ... ARUPLabs #Hemolytic #Anemia ... #workup #hematology
Approach to Thyroid Function Tests in the Evaluation of Hyperthyroidism • Low TSH, Low normal T4
• Low TSH, Low normal ... Hyperthyroidism: Work-up ... Can repeat labs ... Hyperthyroidism #algorithm ... endocrinology #TFTs #TSH #Interpretation
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Drug-induced AIHA - Abnormal ... immune-complex hemolytic anemia ... Prosthetic heart valves ... #Causes #Hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... levels - Usually normal ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
sedimentation rate + Normal ... Cytopenias • Cardiac valve ... lymphopenia, low PLT • Anemia ... , Serositis Labs ... flares • CRP normal
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... that a one-off value ... Better call hematology ... exogenous, EPO levels: normal ... #workup #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
-70 y/o • 2/3 Males ... mainly in the oral ... • No CRAB - no anemia ... Oncology #Diagnosis #Workup ... #Hematology
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