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hematology oncology differential management aplastic cancer chronic cll differentiation gap headache leukemia lymphocytic mnemonic myelodysplasia myelodysplastic phantoms platelets protein proteingap
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... and symptoms: ... • Recurrent infections ... or acute leukemia ... #treatment #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... and viral infections ... #Algorithm #hematology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Syndrome Acute ... Syndrome Symptoms ... Fever (75%) • Encephalopathy ... enzymes ↑ • Mild anemia ... antibody test) Treatment
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
(MDS) (normal or ... Treatment: ... • Improve the symptoms ... antithymocyte globulin ... #oncology #hematology
Approach to Headaches - Differential Diagnosis Algorithm Red flags (PHANTOMS): • Pattern change, progressively worse, papilledema •
papilledema • Horner syndrome ... history of cancer, HIV ... ) • Systemic symptoms ... arteritis • Acute ... #Algorithm #neurology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
: >3 symptoms, or ... : Infection (sepsis ... 500 mg QD until normal ... #APML #diagnosis ... #management #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... petechiae) • Frequent infections ... • Parvovirus infection ... blood cells appear normal ... #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... infections (acute ... gastric tumors • Hematology ... #differential #diagnosis ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... weeks without infection ... Physical Exam/Signs ... • Neutropenia, anemia ... workup #oncology #hematology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
clonal evolution to acute ... median age at diagnosis ... disease tolerate anemia ... may result in an infection ... #algorithm #hematology
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