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diagnosis management hematology dermatology lupus sle adultonset behcet cancer causes coagulation comparison cord cryofibrinogenemia cutaneous differential disorders disseminated druginduced erythematosus
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... MAS, Visceral, DIC ... CK, normal biopsy ... diagnosis #management #treatment ... #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... Thrombocytopenia - Normal ... • Severe Liver Disease ... + Bleeding Treatment ... - APTT < 1.5 x normal
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... of SLE versus DIL ... life-threatening • Treatment ... Evolution: Chronic disease ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... CRP - Usually normal ... - CRP: Usually normal ... Evolution: Chronic disease ... comparison #table #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... association • M > F Clinical ... (Clinical Dx). ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cooled from the normal ... Cryofibrinogenemia Clinical ... Diagnosis: • + Clinical ... Antiphospholipid syndrome ... skin necrosis • DIC
Purpura fulminans is a particularly malignant form of S-DIC associated with hemorrhagic infarction of dermal arteries.
infarction of dermal ... suggesting that this disease ... represent an overlap syndrome ... purpura (TTP) #Clinical ... #Photo #Purpura
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 Cutaneous larva migrans skin Rash 25 F recent Caribbean vacation, walked barefoot on sand and now with
Diagnosis is clinical ... No treatment is ... larva #migrans #skinRash ... #dermatology #clinical ... #photo
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... Diagnosis: • A clinical ... and lower jaw Treatment ... osteoarticular and skin disease ... #Rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
salivary ducts Clinical ... • Nephrogenic DI ... Adenocarcinoma Treatment ... Pharmacologic: • Severe oral ... #Rheumatology #
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