24 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Syndrome and Acute ... ) Three syndromes ... child * Severe cases ... #hematology #diagnosis ... #table #comparison
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... child * Severe cases ... #AFLP #Obstetrics ... #OBGyn #Hematology ... #Diagnosis #Comparison
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Syndrome (Hemolysis ... Disease #Pregnancy #hepatology ... obstetrics #hepatitis #comparison ... #differential #diagnosis ... #icp #HELLP #AFLP
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Pregnancy - AFLP ... , HELLP Moderate ... disease US — Normal ... Others #LFTs #Hepatology ... #Algorithm #Causes
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
- Differential Diagnosis ... • Congenital: HELLP ... , Portal vein thrombosis ... #Differential #Diagnosis ... #causes #hepatology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... antiphospholipid syndrome ... - Pregnancy: HELLP ... Cirrhosis with portal ... #Framework #hematology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... = nonspecific (nausea ... Preeclampsia, HELLP ... iMedEducation #AFLP ... Liver #Pregnancy #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... • Pregnancy: HELLP ... #algorithm #hepatology
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... >10 mmHg - clinically ... and hepatorenal syndrome ... • Budd Chiari syndrome ... #causes #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... • ALT & AST normal ... • Bilirubin - Normal ... obstruction • ALP ... #workup #hepatology