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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE #hematology ... #rheumatology #
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
cooled from the normal ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
sedimentation rate + Normal ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... flares • CRP normal ... Erythematosus #Diagnosis #Rheumatology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
an inhibitor of normal ... to have 50% of normal ... the test to be normal ... Study #diagnosis #hematology ... pathophysiology #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
of Anemia with Normal ... - Decreased/NormaI ... PRV, Chronic) Normal ... Polychromatic Macrocytes, Normal ... Algorithm #Causes #Hematology
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Prolonged PT (INR), Normal ... Prolonged PTT, Normal ... Prolonged PTT, Normal ... Algorithm #Causes #Hematology
Summary of haemotology cell lineages and the malignancies associated with them. Visit gramproject.com for more medical
Summary of haemotology ... #algorithm #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Infiltration: • Hematologic ... and non-hematologic ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... Inflammatory Conditions: Rheumatologic ... Diagnosis #Algorithm #hematology
Calculating a Reticulocyte Index (RI)
Reticulocyte Index = Absolute Reticulocyte Count / Maturation Correction
Absolute Reticulocyte Count =
Patient's Hct / Normal ... Index #RI #RPI #hematology