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diagnosis management sle signs systemic classification algorithm ana antibodies antinuclear autoantibodies comparison complications disorders druginduced hematology lymphomas lymphoproliferative mimickers musculoskeletal
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... #Erythematosus ... #SLE #MSK #Musculoskeletal ... Complications #pathophysiology ... #signs #symptoms
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Nephropathy 16% - Oral ... #Erythematosus ... autoantibodies #signs #symptoms ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... : • Symptoms limited ... flares • CRP normal
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... likely it will be clinically ... erythematosus ( ... ANA #patterns #rheumatology ... #diagnosis #differential
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms ... CRP - Usually normal ... Erythematosus ( ... comparison #table #rheumatology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
can have extra nodal ... pattern of spread, B symptoms ... Amy Chung, MD, MSc ... Classification #pathophysiology ... #Hematology #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Recurrent oral ... such as systemic lupus ... erythematosus, ... Presentation - Systemic Symptoms ... #diagnosis #rheumatology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... renal failure Clinical ... skin (16-32%): lupus ... anterior/posterior MSK ... ), liver (pain/abnormal
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Transverse Myelitis - Clinical ... Bilateral signs and/or symptoms ... Sjogren's • CSF: - Abnormal ... management #neurology #differential
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
including systemic lupus ... erythematosus ( ... cell lymphoma Pathophysiology ... and the systemic symptoms ... phosphatase - Normal
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