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differential causes management workup nephrology ddxof hematology evaluation peds em cardiology pulmonary endocrinology pediatrics dermatology neurology im gastroenterology obgyn treatment
RHABDOMYOLYSIS • Characterized by skeletal muscle breakdown & necrosis. • Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. • Defined based
Creatine kinase (CK ... Defined based on CK ... • Half-life of CK ... peaks in 3 days, & normalizes ... and cefdinir #CK
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Creatine kinase (CK ... CK may increase ... The definitive diagnosis ... first 3 days, and normalizes ... , confirms the diagnosis
Usmle step 2 ck Pulmonary diseases (High yield points) #usmle #algorithm
Usmle step 2 ck ... points) #usmle #algorithm
ICU Hypotension - Evaluation Algorithm OFTEN Mnemonic: OWN THE PULSE PRESSURE FEEL YOUR PATIENT'S LEGS TEST FOR FLUID
Hypotension - Evaluation Algorithm ... ECHO/POCUS NORMALIZE ... Hypotension #Evaluation #Algorithm
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
weakness • Elevated CK ... rash • Elevated CK ... Elevated ESR, Normal CK ... mildly elevated CK ... #differential #diagnosis
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
Clotting test normalizes ... test does not normalize ... Mixing #Study #diagnosis
Causes of Peripheral Weakness - With and Without Sensory Changes - Differential Diagnosis Algorithm With Sensory Changes:
- Differential Diagnosis ... Algorithm With ... involvement, elevated CK ... #Differential #Diagnosis ... #Algorithm #Causes
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Weakness, Normal CK ... Weakness, Incr CK ... therapy), Normal CK ... signs #symptoms #diagnosis
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
: Proximal • CK ... : Proximal • CK ... Associated Features: Diagnosis ... over years, often diagnosed ... #differential #diagnosis
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Causes of Elevated CK ... Levels Acute CK ... ASYMPTOMATIC: Macro CK ... Kinase #Elevated #CK ... #differential #diagnosis
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