13 results
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
rimmed vacuoles HIV myopathy ... load Drug-induced myopathy ... Gemcitabine Lupus Myopathy ... 5-15% of lupus myopathy ... Myositis #Myopathies #myopathy
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Myopathies #ESR #CK ... Dermatomyositis #muscle ... #Hypothyroid myopathy ... #Muscle stiffness ... #Muscle pain
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Levels Acute CK ... Critical Illness Myopathy ... ): • PROXIMAL MUSCLE ... - Inflammatory myopathy ... polymyositis, necrotizing myopathy
RHABDOMYOLYSIS
•	Characterized by skeletal muscle breakdown & necrosis. 
•	Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. 
•	Defined based
Characterized by skeletal muscle ... Creatine kinase (CK ... • Half-life of CK ... peaks in 3 days, & normalizes ... useful marker of muscle
Causes of Peripheral Weakness - With and Without Sensory Changes - Differential Diagnosis Algorithm
With Sensory Changes:
Differential Diagnosis Algorithm ... Oculomotor • Myopathy ... - Proximal muscle ... involvement, elevated CK ... Differential #Diagnosis #Algorithm
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Statin Induced Muscle ... Statin-Associated Muscle ... • The onset of muscle ... Diagnosis: • CK ... (IMNM) • Muscle
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
Hypothyroid Myopathy ... which impairs musde ... Asymptomatic CK ... → Muscle hypertrophy ... #Hypothyroid #Myopathy
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Differential Diagnosis Algorithm ... • Congenital Myopathy ... - Proximal muscle ... involvement, elevated CK ... Differential #Diagnosis #Algorithm
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... associated with higher CK ... greater level of muscle ... and anti-HMGCR myopathy
Usmle step 2 ck
Pulmonary diseases (High yield points)
#usmle #algorithm
Usmle step 2 ck ... yield points) #usmle ... #algorithm