13 results
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
rimmed vacuoles HIV myopathy ... load Drug-induced myopathy ... Gemcitabine Lupus Myopathy ... 5-15% of lupus myopathy ... Myositis #Myopathies #myopathy
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Myopathies #ESR #CK ... Dermatomyositis #muscle ... #Hypothyroid myopathy ... #Muscle stiffness ... #Muscle pain
RHABDOMYOLYSIS
•	Characterized by skeletal muscle breakdown & necrosis. 
•	Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. 
•	Defined based
Characterized by skeletal muscle ... Creatine kinase (CK ... • Half-life of CK ... peaks in 3 days, & normalizes ... useful marker of muscle
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Levels Acute CK ... Critical Illness Myopathy ... ): • PROXIMAL MUSCLE ... - Inflammatory myopathy ... polymyositis, necrotizing myopathy
Causes of Peripheral Weakness - With and Without Sensory Changes - Differential Diagnosis Algorithm
With Sensory Changes:
Differential Diagnosis Algorithm ... Oculomotor • Myopathy ... - Proximal muscle ... involvement, elevated CK ... Differential #Diagnosis #Algorithm
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
Hypothyroid Myopathy ... which impairs musde ... Asymptomatic CK ... → Muscle hypertrophy ... #Hypothyroid #Myopathy
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Statin Induced Muscle ... Statin-Associated Muscle ... • The onset of muscle ... Diagnosis: • CK ... (IMNM) • Muscle
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Differential Diagnosis Algorithm ... • Congenital Myopathy ... - Proximal muscle ... involvement, elevated CK ... Differential #Diagnosis #Algorithm
Usmle step 2 ck
Pulmonary diseases (High yield points)
#usmle #algorithm
Usmle step 2 ck ... yield points) #usmle ... #algorithm
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Creatine kinase (CK ... present in skeletal muscle ... of underlying muscle ... first 3 days, and normalizes ... useful marker of muscle