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nephrology differential algorithm hypokalemia kidney management potassium classification defects epithelial gitelman hyperkalemia k metabolic metabolicacidosis metabolicalkalosis pathophysiology pediatrics stones syndrome
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
Inherited Defects ... Epithelial Cells Renal ... tubular acidosis ... #Diagnosis #Differential ... #Table
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm GI Losses - Gastric • Vomiting • NG suction GI
Causes of Metabolic ... - Differential Diagnosis ... Losses - Impaired tubular ... MetabolicAlkalosis #NonGap ... #Causes
Hypokalemia - Differential Diagnosis Poor Intake - Starvation - Anorexia GI Losses - Vomiting / NG
Mineralocorticoid excess - Renal ... tubular acidosis ... #Low #Potassium ... #Table #Classification ... #Causes
Causes of Non-Gap Metabolic Acidosis - Differential Diagnosis Algorithm Normal Anion Gap (<14) (Loss of Bicarbonate) -
Causes of Non-Gap ... Metabolic Acidosis ... Diarrhea • Fistula Renal ... Cell Problem - Low ... MetabolicAcidosis #NonGap
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... only if no clear cause ... Elimination (see Table ... ) • Low K diet ... Treatment #potassium #nephrology
Metabolic Causes of Kidney Stones in Children • Calcium Oxalate: Primary Hyperoxaluria type 1-3, Secondary Hyperoxaluria
Metabolic Causes ... Tubular Acidosis ... Syndrome type 1-4, Lowe ... (Oculo-Cerebro-Renal ... #differential #diagnosis
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
• Inherited (AR) ... alkalosis • Normal or low ... • Hypokalemia (renal ... tubular acidosis ... Gitelman #Syndrome #diagnosis
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