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diagnosis management hematology syndrome differential signs symptoms treatment complications neurology arthritis causes cppd erythematosus gout lupus msk ophthalmology sle systemic
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Non-Malignant • Amyloidosis ... • Gaucher's Disease ... Glycogen Storage Disease ... myelofibrosis) Inflammatory ... Algorithm #Causes #Hematology
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
(AA) → Chronic Inflammatory ... Clinical suspicion ... the extent of disease ... Clinical Manifestations ... • Circulating inflammatory
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Cerebrovascular Disease ... , PRES Pathophysiology ... Treatment: • Inflammatory ... CNS #neurology #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
ANA ≠ Autoimmune Disease ... likely it will be clinically ... Drug-Induced, Inflammatory ... Bowel Disease, ... ANA #patterns #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... production of pro-inflammatory ... accumulation of clinical ... Assessment • Clinical ... treatment #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
background of a highly inflammatory ... release of pro-inflammatory ... fever syndromes Clinical ... Fever is the main clinical ... #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
(COVID-19) • Inflammatory ... Cryofibrinogenemia Clinical ... Diagnosis: • + Clinical ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Syndrome Systemic disease ... association • M > F Clinical ... (25-75%): Inflammatory ... Behcet syndrome (Clinical ... signs #symptoms #rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Somatic) Syndrome Clinical ... Syndrome: • Common Clinical ... thromboembolic disease ... and/or 2) Inflammatory ... Autoinflammatory #Somatic #rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... • Chronic lung disease ... Gastrointestinal inflammatory ... disease • ... hypogammaglobulinemia #immunology #hematology
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