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diagnosis hematology differential hemeonc myelodysplastic treatment acidosis aplastic chronic cll criticalcare emergencies hemophagocytic hlh lactate lactic lymphocytic lymphohistiocytosis myelodysplasia oncologic
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... Myelodysplastic #Syndrome ... #MDS #Diagnosis ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... myelodysplastic syndrome ... virus (EBV) • Leukemia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
count ↑ PLT • ↑ PBS ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Hematology #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Myelodysplastic syndromes ... formed or don’t work ... age 70 years Symptoms ... diagnosis #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... • Neutropenia, anemia ... • Richter’s Syndrome ... • Sezary syndrome ... #diagnosis #workup
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
TLS (tumor-lysis syndrome ... decompression SVC syndrome ... Hyperviscosity syndrome ... Cytokine-release syndrome ... Differentiation syndrome
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal Syndromes ... Pulmonary Renal Syndromes ... • Inflammatory eye ... or serologies + symptoms ... Pulmonary #Renal #Syndromes
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Shock, Severe Anemia ... Ischemia, Compartment Syndrome ... Beta-Agonists, ↑ work ... Toxins: - Propofol (PRIS ... in Short Bowel Syndrome
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... patients with the HLH syndrome ... Macrophage Activation Syndrome ... Common Signs and Symptoms ... - Cytopenias (anemia
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