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hematology leukemia chronic differential emergencies fever hemeonc immune inflammatory lymphocytic mds myelodysplasia myelodysplastic oncologic pfapa reconstitution syndromes workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... ALL Symptoms: ... ) CLL Symptoms: ... Leukemia #Hematology #Oncology ... #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Syndrome in APML ... : >3 symptoms, or ... #Syndrome #APML ... #diagnosis #management ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Diagnosis: • ... • Richter’s Syndrome ... Transform to DLBCL, PML ... #workup #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
“big & sticky” cells ... ± tocilizumab; call ... Differentiation ... Treatment: continue differentiating ... #HemeOnc #Diagnosis
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... increase in CD4+ cells ... weeks for most OI ... #Inflammatory #Syndrome ... #Management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... transformation to AML ... progression to AML ... #diagnosis #hematology ... #oncology
PFAPA Syndrome - Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis EPIDEMIOLOGY: PFAPA is the most common syndrome entailing
The diagnosis of ... edema around the eyes ... ), - Muckle–Wells ... be helpful in differentiating ... #Diagnosis
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