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rheumatology treatment differential arthritis causes dermatology erythematosus hemophagocytic hepatology lupus lymphohistiocytosis sle systemic workup algorithm joint neurology oncology product reactions
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... • Fever is the main ... clinical manifestation ... #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... age, however the disease ... also observed in adults ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... accumulation of clinical ... : SLE+++, Adult-onset ... Still disease, ... #management #treatment
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... Differential Diaqnoses ... Complications: MAS ... #diagnosis #management
Vascular Joint Pain - Differential Diagnosis Algorithm - Constant Pain (Ischemia) - Acute Onset -
- Differential Diagnosis ... Peripheral Vascular Disease ... Marfan's Syndrome ... compressing the blood ... Vascular #JointPain #MSK
Campylobacter Clinical • Fever • Abdominal pain • Diarrhea (bloody stools) • Vomiting
Campylobacter Clinical ... • Abdominal pain ... • Diarrhea (bloody ... Guillain-Barré syndrome ... Campylobacter #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
HLH is a critical ... to find in an adult ... ▪ Autoimmune diseases ... (often termed MAS-HLH ... #Management #Hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Epidemiology: • Young adults ... association • M > F Clinical ... (Clinical Dx). ... Nonsurgical abdominal pain ... #diagnosis #management
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
and Management ... Summary Clinical ... hot, swollen, pain ... osteomyelitis, trauma ... necrosis, Lyme disease
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... cells can indicate disease ... Lymphocytosis: Absolute blood ... • Richter’s Syndrome ... workup #oncology #hematology
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