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rheumatology treatment dermatology hemophagocytic lymphohistiocytosis syndrome differential activation adultonset arthritis classification coagulation cutaneous dic disseminated eschar gangrenosum hemeonc hodgkins intravascular
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... fever syndromes Clinical ... Fever is the main clinical ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... : SLE+++, Adult-onset ... Still disease, ... Drugs, Unknown cause ... #management #treatment
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... Differential Diaqnoses ... Complications: MAS ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... age, however the disease ... also observed in adults ... #management #treatment ... #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Epidemiology: • Young adults ... common in Asia • HLA-B51 ... association • M > F Clinical ... syndrome (Clinical ... #management #signs
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
HLH is a critical ... hyperinflammatory syndrome caused ... ▪ Autoimmune diseases ... (often termed MAS-HLH ... #Management #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
history • Young adults ... Hodgkin Lymphoma - Clinical ... number of sites of disease ... classification #hematology ... #oncology #management
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Arthritis Differential Diagnosis ... Noninflammatory • Trauma ... weeks) Can Be Caused ... arthritis • Adult ... #MSK #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Recent history of trauma ... organ damage Clinical ... • Severe Liver Disease ... #Coagulation #diagnosis ... #management #hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
super-antigen mediated disease ... Transverse Myelitis - Clinical ... bouts of HTN Diagnostic ... disease - Sjogren ... #management #neurology
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