22 results
treatment causes hematology rheumatology syndrome hemophagocytic lymphohistiocytosis nephrology sclerosis signs summary symptoms activation adultonset als amyotrophic arteritis arthritis behcet central
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... fraction < 20% Differential ... Complications: MAS ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... fever syndromes Clinical ... Fever is the main clinical ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... : SLE+++, Adult-onset ... Still disease, ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... age, however the disease ... also observed in adults ... Diagnosis via genetic ... #management #treatment
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Demyelinating Disease ... Transverse Myelitis, Trauma ... heavy metals), Critical ... Weakness #Causes #differential ... #diagnosis #neurology
Causes of Peripheral and Central Vertigo PERIPHERAL VERTIGO 1. Benign paroxysmal positional vertigo (BPPV) - Short-lived (typically less
often in older adults ... Méniére's disease ... Disease onset usually ... Vertigo #Causes #differential ... #diagnosis #neurology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
HLH is a critical ... to find in an adult ... ▪ Autoimmune diseases ... (often termed MAS-HLH ... Clinical Presentation
Hearing Loss - Differential Diagnosis Framework Hearing Loss Types: • Conductive • Sensorineural • Mixed Presbycusis is the most common type
Hearing Loss - Differential ... Diagnosis Framework ... common type in adults ... include a: • Neurologic ... #Diagnosis #otology
Facial Swelling - Differential Diagnosis Framework for Facial Edema Infectious: • Dental abscess • Ludwig's angina • Vincent's angina • Cellulitis •
Facial Swelling - Differential ... Diagnosis Framework ... polymyositis • Adult-onset ... Still's disease ... #Diagnosis #PhysicalExam
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Epidemiology: • Young adults ... association • M > F Clinical ... skin injury) • Neurologic ... ) Differential Diagnosis ... #management #signs
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