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differential hematology treatment algorithm causes rheumatology acidosis activation adultonset cell criticalcare dehydrogenase diabetes dm2 dmii elevated elevation hemeonc hemophagocytic histiocytosis
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... - Differential Diagnosis ... • Pulmonary infarction ... Demand ischemia • Trauma ... #LDH #Lactate
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Differential Diaqnoses ... Complications: MAS ... hepatitis • Pulmonary ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... arthritis (sJIA) • Adult-onset ... Still disease ... Triglycerides • ↑ Lactate ... #Diagnosis #Management
Shock - Differential Diagnosis Framework - MAP <65. SBP <90, drop in SBP > 40 -
- Differential Diagnosis ... , Severe Valve Disease ... • Obstructive: Pulmonary ... Abdominal compartment syndrome ... algorithm #treatment #management
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
- Differential Diagnosis ... presentations and disease ... output - Acute pulmonary ... - Compartment syndrome ... #typea #typeb #classification
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Differential Diagnosis ... Rhabdomyolysis: • Trauma ... Aldolase ↑ • LDH ... of underlying disease ... Isotonic fluid/Lactated
Type 2 Diabetes - Screening, Diagnosis and Management Algorithm Lifestyle Modifications (Diet and Exercise) -> Start
Diabetes - Screening, Diagnosis ... ≤ 7.0 % - Most adults ... Endocrinopathies (Cushing Syndrome ... PCOS), Pancreatic Disease ... algorithm #DM2 #DMII #Classification
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
history • Young adults ... classical HL (LDHL ... number of sites of disease ... #classification ... hematology #oncology #management
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
both children and adults ... • Pulmonary Symptoms ... particularly in adult ... DIAGNOSIS • Imaging ... #Management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... to find in an adult ... - Common in: Adults ... ▪ Autoimmune diseases ... (often termed MAS-HLH
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