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management differential infectiousdiseases rheumatology infections clinical hematology hemophagocytic hlh lymphohistiocytosis stills adultonset aids aosd bacteria brain cap cardiology cns community
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Differential Diaqnoses ... Complications: MAS ... hepatitis • Pulmonary ... #treatment #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Syndrome (MAS) ... the secondary or acquired ... manifestation of MAS ... Plasma exchange #MAS ... #Syndrome #Diagnosis
Rhodococcus - Microbiology Overview Microbiology: • Facultative, intracellular, nonmotile, non-spore-forming • Aerobic acid-fast gram-positive coccobacilli • Produces
Transmission (Zoonotic disease ... inoculation due to trauma ... Diagnosis Treatment ... #diagnosis #treatment ... #pulmonary #Bacteria
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... Purtilo (XLP) Acquired ... : SLE+++, Adult-onset ... Still disease,
Leptospirosis Pathogen: Leptospira (interrogans, kirschneri, noguchii) Risk Factors: • Occupational exposure - Farmers, ranchers, trappers, veterinarians • Recreational
failure • Severe pulmonary ... disease ARDS Diagnosis ... manifestations • MAT ... Leptospirosis #Leptospira #microbiology ... #diagnosis #treatment
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... mL Gf consider MAS ... Treatment - Mild ... : NSAIDS Treatment ... anti-lL6R, anti-ILI #Adult
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
): • Acquired ... disease may complicate ... MAC pulmonary disease ... Diagnosis Of NTM ... • Microbiologic
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... the serum that has ... cell enzymes - Acquired ... • Pulmonary infarction ... Demand ischemia • Trauma
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Community Acquired ... Pneumonia (CAP) - Diagnosis ... be initiated in adults ... #Management #treatment ... #Pulmonary #Community
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
to find in an adult ... • Secondary (Acquired ... - Common in: Adults ... ▪ Autoimmune diseases ... (often termed MAS-HLH
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