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diagnosis differential algorithm management workup anemia oncology aplastic disorders encephalopathy enzymes heon hepatic hypereosinophilia leukemia lfts liver macrocytic microangiopathy microcytic
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Initial labs: CBC, BMP ... hemosiderin • PT/aPTT normal ... Management #Algorithm #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
practices that could cause ... patients if the cause ... or if a primary hematologic ... When do you do a BM ... #Workup #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Normal range 11.5% ... in bone marrow (BM ... under 2%, then BM ... Diagnosis #Workup #Hematology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... initial response to abnormal ... *Abnormal USS may ... aminotransferase; BMI ... #Algorithm #Hepatology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Causes of Neutropenia ... the most common cause ... replacing the BM ... replacing the BM-common ... #hematology
Hepatic Encephalopathy Treatment • Lactulose: - Oral liquid, 30-45mL 2-4x/day, titrated to 2-4
titrated to 2-4 BMs ... For refractory cases ... Treatment #management #hepatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Toxic injury to BM ... and petechiae Causes ... syndrome (MDS) (normal ... megakaryocytes and a normal ... Anemia #oncology #hematology
When to look for clonal/neoplastic hypereosinophilia (HEo)? - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
Exclusion of frequent causes ... - Myelogram/BM ... Diagnosis #Signs #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
cells - Blood & BM ... • Cytopenia -> BM ... -> AML: Blast crises ... #Leukemia #Hematology
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