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causes injury transaminitis hematology management abnormal fatty gastroenterology hepatitis obgyn obstetrics pregnancy adrenalmass aflp anemia bleeding bruising chemistry disease drug
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Drug #induced #Liver ... Idiosyncratic #differential
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Differential Diagnosis ... (>1000): • DILI ... (Drug-induced liver ... Diagnosis #hepatology
Evaluation abnormal liver tests in pregnancy - Cholestatic Pattern - Hepatocellular Pattern #LFTs #transaminits #pregnancy #obgyn #obstetrics #hepatology #diagnosis
Evaluation abnormal liver ... Hepatocellular Pattern #LFTs ... obgyn #obstetrics #hepatology ... #diagnosis #differential ... #algorithm
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Algorithm DILI ... Alcohol-related liver ... #DrugInduced #Liver ... #Algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... : Liver Injury ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Diagnosis Algorithm ... Sequestration Disordered ... Iatrogenic) • Liver ... #Diagnosis #Algorithm ... #Causes #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... injury #hepatitis #differential ... #diagnosis #algorithm ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis ... #LFTs #RValue #
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Diagnosis Algorithm ... • Others #LFTs ... #Hepatology #LiverEnzymes ... Diagnosis #Algorithm
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Diagnosis Algorithm ... WBCs - Normal Liver ... Deficiency - Abnormal Liver ... Tests • Liver ... #Diagnosis #Algorithm
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