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diagnosis algorithm transaminitis injury abnormal aflp alcoholic autoimmune causes gastroenterology obstetrics portal pregnancy syndrome treatment aclf acute ah air chemistry
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... (Drug-induced liver ... Hepatopathy (shock liver ... LouLectures #Liver ... Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... #Patterns #Liver ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... Failure (ACLF) Clinical ... disease, liver ... support, or liver ... Failure #Cirrhosis #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Drugs • AIH ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... Hepatocellular Liver ... #Diagnosis #hepatology ... Transaminitis #LFTs
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Drug #induced #Liver ... gastroenterology #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Viral, Ischemia, AIH ... Burak @kwburak #LFTs ... Algorithm #diagnosis #hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... disease to acute liver ... hepatocellular pattern of liver ... (eg Viral) Management ... #Management #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Interpretation of LFTs ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Alcoholic Hepatitis - Management Algorithm 1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... - Management Algorithm ... survival in severe AH ... can be bridge to Liver ... #treatment #hepatology
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