13 results
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... ALP - Biliary ... SinaiBmoreIMRes #Liver ... Transaminitis #diagnosis #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... Hepatocellular Liver ... Transaminitis #diagnosis #differential ... #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
(ALP) Elevation ... - Increased ALP ... disturbance (obstructed liver ... Highest • Bone • Liver ... #ALP #Elevation
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... or AST > ALP): ... Wilsons, Pregnancy - AFLP ... Cholestatic Pattern (ALP
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Chemistries ... Interpretation of LFTs ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... Hepatocellular Liver ... #Diagnosis #hepatology ... Transaminitis #LFTs
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Of Clinical Importance ... in 1923 Low ALP ... 1948 by Rathbun ALP ... synthesized in: liver ... #hepatology #diagnosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... • Pregnancy - AFLP ... • Others #LFTs ... #Hepatology #LiverEnzymes
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... hepatocytes → Liver ... iMedEducation #AFLP ... #Fatty #Liver #
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... of Pregnancy (AFLP ... features: Liver ... #differential # ... diagnosis #icp #HELLP #AFLP