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diagnosis liver transaminitis algorithm function gastroenterology interpretation tests aclf acute aflp causes chemistry chronic cirrhosis druginduced failure fatty hepatitis hepatocellular
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... Chronic - ongoing ↑ LFTs ... #Liver #Injury # ... Idiosyncratic #differential ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... (>1000): • DILI ... (Drug-induced liver ... injury) • Ischemic ... Diagnosis #hepatology
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Drugs and Classes ... and Type of Liver ... Injury #Medications ... #Differential # ... #LiverInjury #Hepatology
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 Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) Clinical ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... Failure #Cirrhosis #Hepatology ... gastroenterology #management
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... Injury Differential ... #Injury #Differential ... Transaminitis #LFTs
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
(LFTs) - Normal ... hepatocellular injury ... impaired uptake (drugs ... Function #Tests #LFTs ... Interpretation #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Unconjugated Bili ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... Maternal Support - Critical ... #Pregnancy #hepatology ... obgyn #diagnosis #management
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