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diagnosis algorithm transaminitis causes function gastroenterology hepatitis interpretation pathophysiology pharmacology tests abnormal acidosis aclf acromegaly activation acute aflp aih antibiogram
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... Chronic - ongoing ↑ LFTs ... or symptoms of liver ... #Liver #Injury # ... Idiosyncratic #differential
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... (>1000): • DILI ... (Drug-induced liver ... injury) • Ischemic ... Diagnosis #hepatology
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Drugs and Classes ... and Type of Liver ... Injury #Medications ... #Differential # ... #LiverInjury #Hepatology
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 Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... Clinical Guidelines ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... #Hepatology #gastroenterology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... failure 1) Hepatocellular ... Injury Differential ... #Injury #Differential
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... (LFTs) - Normal ... hepatocellular injury ... impaired uptake (drugs ... Interpretation #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Failure (ALF): ... • Liver injury ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... malaise) → Acute liver ... Transfer to a liver ... #AFLP #Fatty #Liver
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... derangement of liver ... #LFTs #Abnormal ... #Algorithm #Hepatology ... #Differential #
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... failure ... hepatocellular pattern of liver ... injury, though ... #Hepatology
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