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 End Stage Liver Disease (Cirrhosis) - Complications 
 • Ascites
 • Esophageal Varices
 • Hepatic
End Stage Liver ... Disease (Cirrhosis ... Complications • Ascites ... (HRS) • Liver ... SBP) #ESLD #Liver
Cirrhosis - Pathophysiology
 - Ascites Formation
 - Dilutional Hyponatremia
 - Hepatorenal Syndrome
 - Spontaneous Infections

#Cirrhosis #Pathophysiology
Cirrhosis - Pathophysiology ... - Ascites Formation ... - Hepatorenal Syndrome ... Pathophysiology #hepatology ... #liver
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG)
SAAG ≥ 1.1:
 - Ascitic protein
protein ≤ 2.5 g/dL: Cirrhosis ... Late Budd-Chiari syndrome ... , Massive liver ... leak, Nephrotic syndrome ... albumin #gradient #hepatology
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Ascites - Differential ... Diagnosis Chronic liver ... disease (cirrhosis ... failure - 3-5% Cirrhosis ... Fitz-Hugh-Curtis syndrome
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
- Budd-Chiari syndrome ... Liver disease ... - Cirrhosis ... - Acute fatty liver ... - Nephrotic syndrome
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
>10 mmHg - clinically ... of portal HTN: ascites ... portal HTN: • Ascites ... sarcoidosis) • Liver ... metastasis • Fatty liver
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... Failure (ACLF) Clinical ... months without treatment ... disease, liver ... support, or liver
Indications for Albumin for Management of Cirrhosis
 • Large volume paracentesis (>5 liter) - 8g per
of Cirrhosis ... of ascites removed ... • Hepatorenal syndrome ... #Cirrhosis #treatment ... #hepatology
Approach to the Hospitalized Patient with Cirrhosis
1) Recognize and Manage Decompensation
 • Ascites
 • Variceal Bleeding
Decompensation • Ascites ... • Hepatorenal Syndrome ... Portosystemic Shunt • Liver ... #diagnosis #treatment ... #management
Clinical Examination for Liver and Biliary Diseases
1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Clinical Examination ... for Liver and Biliary ... Aspiration of ascitic ... #physicalexam #cirrhosis ... #liver #disease