31 results
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Liver Failure ( ... ACLF) Clinical Guidelines ... disease, liver ... #Hepatology #gastroenterology
Clinical manifestations of acute liver failure 

Brain: 
Hepatic encephalopathy,  
Cerebral edema,  
Intracranial hypertension,
Clinical manifestations ... of acute liver ... abnormalities Liver ... Heart: High output ... #liver #failure
Flapping tremors of Asterixis

DDx
- Decompensated cirrhosis or acute liver failure.
- Renal failure /azotemia.
- Respiratory failure with
Decompensated cirrhosis or acute ... liver failure ... - Renal failure ... #PhysicalExam #clinical ... #diagnosis #video
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
and Acute Fatty ... Liver of Pregnancy ... Hemolysis, Elevated Liver ... exchange 3) Fatty liver ... coagulation defects and liver
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... liver failure rapidly ... Transfer to a liver ... #AFLP #Fatty #Liver
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Findings in Hepatic / Liver ... —100-fold with acute ... liver failure; ... hepatocytes; in chronic liver ... has exhausted liver
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
Infiltrative disease • Acute ... liver failure ... Post-Hepatic: • Heart failure ... • Budd-Chiari syndrome ... Diagnosis #Algorithm #Hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... necrosis HELLP Syndrome ... Hemolysis, Elevated Liver ... Fatty Liver of ... features: Liver
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Chemistries ... Liver Failure ( ... ALF): • Liver ... • Gilbert's syndrome ... #differential #Hepatology
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
- Heart failure ... Liver disease ... fibrosis - Acute ... fatty liver of ... #differential #hepatology