67 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
- Differential ... : • Autoimmune ... (AIHAs) • Alloimmune ... #Anemias #Differential ... Diagnosis #Algorithm #hematology
Anemia - Hemolysis Diagnostic Algorithm
Autoimmune hemolytic anemia
Microangiopathic hemolytic anemia
Probable thalassemia

Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... Diagnostic Algorithm Autoimmune ... hemolytic anemia ... Anemia #Algorithm #hematology ... #diagnosis #differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Immune-mediated: - Autoimmune ... e.g. lupus, CLL, lymphoma ... idiopathic) - Autoimmune ... Extravascular #Causes #differential ... #diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - Differential ... Cold Agglutinin Disease ... #Hemolytic #Anemia ... Diagnosis #Table #hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Congenital Diseases ... • Leukemia • Lymphoma ... Inflammatory and Autoimmune ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
spherocytosis, Autoimmune ... IgM associated lymphoma ... , Malignant lymphoma ... RBC #Morphology #differential ... #diagnosis #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
EBV infection, Autoimmune ... Pylori) - Autoimmune ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm
 • Reactive (Inflammatory / Infectious)
 •
Lymphadenopathy - Differential ... Neoplastic (Leukemia, Lymphoma ... Lymphadenopathy #LAD #Differential ... Algorithm #Causes #Hematology ... #Oncology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... elliptocytosis, autoimmune ... #Anemia #Differential ... Algorithm #workup #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Splenomegaly - Differential ... Malignant • Lymphoma ... Serum Sickness Hemolytic ... Spleen #Enlarged #Differential ... Algorithm #Causes #Hematology