48 results
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... inhibitor) 2) Osmotic ... diuretics (e.g. ... Thiazides-type diuretics ... #pharmacology #nephrology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Pathophysiology - Diuretic ... Sites of Action Diuretics ... canagliflozin 2) Osmotic ... Pathophysiology #Diuretics ... Sites #Action #nephrology
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... • Triamterene OSMOTIC ... DIURETICS • Mannitol ... Tolvaptan #Diuretics ... summary #table #nephrology
Treatment of hyperkalemia via kaliuresis 
step 1 = volume resuscitation if hypovolemic
step 2 = consider fludrocortisone
step
Treatment of hyperkalemia ... determine response to diuretic ... #criticalcare #treatment ... #diuretics #diuresis ... #nephrology #algorithm
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
the Nephron - Diuretics ... Acetazolamide 2) Osmotic ... Diuretics (e.g. ... Pathophysiology #Nephrology ... #Nephron #Diuretics
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
concentrating defect: • Diuretics ... • Osmotic diuresis ... Diagnosis #Causes #nephrology
Hypernatremia Classification and Features According to Volume Status
 - Hypervolemic hypernatremia - Cushing's syndrome, Primary hyperaldosteronism,
hypernatremia - Osmotic ... diuretic, Loop ... diuretics, Postobstructive ... diuresis - Extrarenal ... Comparison #Table #Nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
plasma insulin (treatment ... thiazide-like diuretics ... Postobstructive diuresis ... , Osmotic diuresis ... differential #diagnosis #nephrology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... Methazolamide Osmotic ... diuretics: • ... #Pharmacology #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
• Hypovolemic: Diuretics ... , osmotic (solute ... ) diuresis • Euvolemic ... Workup #Algorithm #nephrology