27 results
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... of action on the ... inhibitor) 2) Osmotic ... #pharmacology #nephrology ... medications #sites #action
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Sites of Action ... Diuretics 1) ... canagliflozin 2) Osmotic ... #Sites #Action ... #nephrology #pharmacology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Hormones Acting ... Their Site of Action ... Acetazolamide 2) Osmotic ... Diuretics (e.g. ... Pathophysiology #Nephrology
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... , Mechanism of Action ... • Triamterene OSMOTIC ... DIURETICS • Mannitol ... summary #table #nephrology
Causes of Polyuria - Differential Diagnosis
Excess Intake of Water:
 • Primary polydipsia (a.k.a. "psychogenic polydipsia")
 •
- Differential Diagnosis ... Solute (a.k.a. osmotic ... diuresis): • ... : Conventional diuretics ... #Causes #nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
- Differential Diagnosis ... concentrating defect: • Diuretics ... • Osmotic diuresis ... #Differential #Diagnosis ... #Causes #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
- Differential Diagnosis ... Workup Algorithm ... , osmotic (solute ... #Workup #Algorithm ... #nephrology #sodium
Hypernatremia Classification and Features According to Volume Status
 - Hypervolemic hypernatremia - Cushing's syndrome, Primary hyperaldosteronism,
hypernatremia - Osmotic ... diuretic, Loop ... diuresis - Extrarenal ... Classification #Features #Diagnosis ... Comparison #Table #Nephrology
Causes of Polyuria - Differential Diagnosis Algorithm
Polyuria - Urine Output > 3L/day, Increased Urine Volume (>2ml/min)
Osmotic
- Differential Diagnosis ... Volume (>2ml/min) Osmotic ... Diuresis Urine ... #Nephrology #Differential ... #Diagnosis #Algorithm
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
plasma insulin (treatment ... , nasogastric suction ... , Osmotic diuresis ... #differential #diagnosis ... #nephrology