46 results
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... canagliflozin 2) Osmotic ... Adenosine #Nephron #Pathophysiology ... Sites #Action #nephrology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Acetazolamide 2) Osmotic ... spironolactone) #Pathophysiology ... #Nephrology #Nephron
Irritable Bowel Syndrome (IBS) Treatment Algorithm

IBS-Constipation:
 • Constipation: Osmotic laxatives
 • Abdominal pain: Antispasmodics

IBS-Diarrhea:
 • Diarrhea:
Syndrome (IBS) Treatment ... Constipation: Osmotic ... Syndrome #IBS #Treatment
Intra-renal urea recycling to maintain the medullary osmotic gradient

Dr. Muner Mohamed @MunerMohamed1

#urea #recycling #osmotic #gradient #pathophysiology
the medullary osmotic ... urea #recycling #osmotic ... #gradient #pathophysiology ... #nephrology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
inhibitor) 2) Osmotic ... #pharmacology #nephrology
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
Pressure (ICP) - Pathophysiology ... lidocaine, +/- pre-treatment ... flow - raise ICP Osmotic ... Agents: • Osmotic ... #neurology #neurosurgery
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Diuretics • Osmotic ... Diagnosis #Causes #nephrology
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
• Triamterene OSMOTIC ... summary #table #nephrology
Drug Induced Kidney Injury
 • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy
 • Osmotic
CAR-T therapy • Osmotic ... diagnosis #algorithm #nephrology
Conceptual Relationship between Volume Responsiveness and Volume Tolerance

Assessing for volume responsiveness would only tell you that
-decreased oncotic ... #Differential #Pathophysiology