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management signs symptoms differential rheumatology syndrome treatment neurology photo dermatology hematology hepatology pulmonary comparison summary algorithm causes endocrinology msk ophthalmology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... Differential Diaqnoses ... • Muscular: normal ... CK, normal biopsy ... #diagnosis #management
Alzheimer's Disease - Summary • Epidemiology • Pathophysiology • Risk Factors • Presentation • Diagnosis •
Alzheimer's Disease ... Epidemiology • Pathophysiology ... Treatment • Clinical ... #Alzheimers #Disease ... #Summary #diagnosis
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
: < 1% Clinically ... Differential Diagnosis ... • Autoimmune diseases ... likelihood of negative clinical ... CBC #hematology #pathophysiology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
Von Willebrand Disease ... bleeding disorder Clinical ... PT/INR • Normal ... VonWillebrand #Disease ... #Diagnosis #Hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
• Clinical features ... also arise in normal ... Noncontiguous spread • Clinical ... Differential Diagnosis ... comparison #oncology #diagnosis
Gaucher Disease Pathophsiology • Lysosomal storage disorder • Deficiency of ß-glucocerebrosidase • Accumulation of glucosylceramide in macrophages Diagnosis
Gaucher Disease ... Pathophsiology ... in macrophages Diagnosis ... in GBA1 gene Clinical ... #Diagnosis #Signs
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... • ALT & AST normal ... • Bilirubin - Normal ... but elevated as disease ... , IgG4 related disease
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Idiopathic • Normal ... involvement: Anti-GBM Disease ... #differential #diagnosis
Osteoarthritis (OA): Clinical findings • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
Osteoarthritis (OA): Clinical ... Disruption of normal ... osteophyte with normal ... Osteoarthritis #OA #pathophysiology ... #diagnosis #signs
Shock Classification Types - Pathophysiology Comparison Obstructive Shock: • Obstructive shock is characterized by a blockage in
Classification Types - Pathophysiology ... Echocardiographic Signs: Normal ... advanced valvular disease ... cardiac chambers and normal ... #criticalcare #diagnosis
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