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diagnosis hematology management hemeonc hemophagocytic hlh lymphohistiocytosis apml chronic classification differentiation emergencies hodgkins leukemia lymphocytic lymphoma macrophage mas mds myelodysplasia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... weeks without infection ... microglobulin Treatment ... Leukemia #diagnosis #workup ... #oncology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... SLE], AOSD) • Infection ... Liver function tests ... Treatment: • Corticosteroids ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... with multiple organ ... following: • Fever ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... Subacute-Acute: • Common: fever ... Differential Diagnosis: Infection ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... petechiae) • Frequent infections ... • Parvovirus infection ... Workup: • Complete ... #oncology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Triggers: ▪ Infections ... Syndrome) 3. ... Fever b. ... underlying trigger: Infections ... Diagnosis #Management #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... • Dyspnea • Fever ... Hodgkin Lymphoma Workup ... Hodgkin Lymphoma Treatment ... #oncology #management
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
if SSTI or port infection ... abdominal pain; full infectious ... work-up - If febrile ... days → add fungal work-up ... ± tocilizumab; call
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Males • Affects all ... Nonspecific symptoms: Fever ... Diagnosis: • Clinical tests ... affected tissue Treatment ... Polychondritis #rheumatology
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