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diagnosis differential emergencies oncologic rheumatology apml cancer differentiation diuresis diuretics excretion hemeonc medications monoclonal nephrology paraproteinemias pharmacology prs sarcoidosis signs
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... Hyperviscosity Syndrome ... of breath • Neurologic ... Hoarseness • Chest and ... Hyperuricemia • Acute renal
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... Renal Syndromes ... and renal involvement ... Goodpasture's cause ... #Renal #Syndromes
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Management Summary ... possibly renal ... symptoms are not caused ... Pulmonary: dyspnea ... anterior/posterior MSK
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Imaging: CXR- pulmonary ... Anaphylaxis, Acute Renal ... APML #diagnosis #management ... #hematology #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Entities That Can Feature ... et diutinum Neurologic ... vascular beds-renal ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Regulating Renal ... irrigation • Management ... Torsemide) • Acute pulmonary ... Kidney stones caused ... Excretion #Diuresis #Nephrology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... Distal (Type I) renal ... Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... Diagnosis #Management
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... ): - Hematologic ... Treat underlying cause ... , hypotension, renal ... failure, pulmonary
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
and renal abnormalities ... affects the skin, neurologic ... cognitive impairment, neurologic ... often causes arthritis ... vasculitis • Cogan syndrome
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