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diagnosis differential hepatology liver management causes transaminitis aki dili disease emesis treatment vomiting workup abdominal aclf aih alcoholic arthritis autoimmune
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... Cirrhosis • Chronic ... Viral Hepatitis ... Hepatopathy • Acute ... Drug-induced liver injury
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... > 20x normal - Acute ... 5-10x normal - Chronic ... Patterns #Liver #Injury ... #hepatology #LFTs
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... #Chronic #Liver ... Cirrhosis #Hepatology #gastroenterology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
dose dependent injury ... presentation • Chronic ... - ongoing ↑ LFTs ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... viral hepatitis ... > 2 • NASH, Chronic ... > 3 • Chronic ... transaminitis #LFTs
Non-ACS Myocardial Injury - Elevated Troponin Differential Diagnosis and Workup Algorithm • Chronic Myocardial Injury: End
Diagnosis and Workup Algorithm ... • Chronic Myocardial ... (ie Sarcoid), Chronic ... Distribution: Acute ... Post-Coronary) • Acute
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... dechallenge • Acute ... or chronic atypical ... e.g. ascites), Chronic ... hepatitis fibrosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... > 2 • NASH, Chronic ... > 3 • Chronic ... #diagnosis #algorithm
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... , Acute biliary ... Sophia_Hayes_MD #Liver #Injury ... #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver Injury ... • Infections: Hepatitis ... Diagnosis #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
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