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diagnosis differential hepatology causes liver management transaminitis aki dili emesis nephrology vomiting abdominal aclf alcoholic chemistry chronic cirrhosis colles dehydrogenase
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... Hepatopathy • Acute ... Viral Hepatitis ... 1000): • DILI (Drug-induced ... liver injury)
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe Acute ... Liver Injury ... - Ichemic hepatitis ... obstruction - Drug-Induced ... liver injury
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced ... Chronic - ongoing ↑ LFTs ... EmoryGastroHep #DILI #Drug ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... > 20x normal - Acute ... Viral Hepatitis ... Patterns #Liver #Injury ... #hepatology #LFTs
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... (AAH) Drug-Induced ... Liver Injury (DILI ... ) Viral Hepatitis ... Cirrhosis #Hepatology #gastroenterology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... dechallenge • Acute ... ascites), Chronic hepatitis ... • Autoimmune hepatitis ... #Diagnosis #Algorithm
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... , Recreational Drugs ... Sophia_Hayes_MD #Liver #Injury ... #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... valproate, azoles), Drugs ... Diagnosis #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Differential Diagnosis Algorithm ... • Viral • Drugs ... • Alcoholic hepatitis ... • Others #LFTs ... Differential #Diagnosis #Algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... viral hepatitis ... viral hepatitis ... Chronic viral hepatitis ... transaminitis #LFTs
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