13 results
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... • Infections: Hepatitis ... Diagnosis #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... Celiac Disease Hepatocellular ... Sophia_Hayes_MD #Liver #Injury ... #algorithm #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
dose dependent injury ... Chronic - ongoing ↑ LFTs ... Calculate R-Value • Hepatocellular ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... ALP) • R > 5: Hepatocellular ... viral hepatitis ... viral hepatitis ... transaminitis #LFTs
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Function Tests (LFTs ... Chronic Viral Hepatitis ... Hepatopathy • Acute ... Viral Hepatitis ... Drug-induced liver injury
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver Injury ... > 20x normal - Acute ... Viral Hepatitis ... Patterns #Liver #Injury ... #hepatology #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... Acute Liver Injury ... Chronic viral hepatitis ... #diagnosis #algorithm
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... alternative causes • Hepatocellular ... dechallenge • Acute ... • Autoimmune hepatitis ... #Diagnosis #Algorithm
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Alcohol-Associated Hepatitis ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... Cirrhosis #Hepatology #gastroenterology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
injuries Hepatic Injury ... : • Early acute ... hepatitisAcute ... Hepatocellular ... Injury - Markedly