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management differential hematology neurology oncology activation behcet brain cerebritis disease effusion emergencies endocarditis erythematosus hemeonc infectiousdiseases lesions leukemia lupus macrophage
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Erythematosus (SLE ... Demyelinating Syndrome ... autoantibodies that will cause ... #rheumatology #
Causes of Pericardial Effusion - Differential Diagnosis Infectious: • Viral: Enterovirus, Herpesvirus, Adenovirus, Parvovirus • Bacterial: Mycobacterium
Causes of Pericardial ... - Differential Diagnosis ... Non-Infectious: • Rheumatologic ... : SLE, Rheumatoid ... #Causes #cardiology
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
Chorioretinitis • Diagnosis ... - Compatible syndrome ... nodules, may also see ... #differential #diagnosis ... #causes #radiology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... Oral aphthae : SLE ... • Arthritis: SLE ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... erythematosus [SLE ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Diagnosis: • Dry ... Hypocomplementemia • Can cause ... Adenocarcinoma Treatment ... #Rheumatology #
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... : CNS manifestations ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Treat underlying cause ... interventional radiology ... ) - Symptoms: CNS ... ) - Treatment: ... Oncology #HemeOnc #Diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... diseases, such as SLE ... tract, and often causes ... chorioretinitis, CNS ... #Rheumatology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
and Differential Diagnosis ... • Autoimmune (SLE ... Cholesterol emboli syndrome ... hematuria, + RF Treatment ... #cardiology #infectiousdiseases
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