18 results
Pathophysiology Based Approach to Hyponatremia - Diagnostic Algorithm

Not the "classic" Volume based approach. 

#Hyponatremia #Algorithm #Pathophysiology
Pathophysiology ... #Hyponatremia #Algorithm ... #Pathophysiology ... #Differential #Nephrology ... #UOsm #Osmolality
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Hyponatremia Differential ... Utilizing Uric Acid ADH ... retention 1) Serum Osmolarity ... 2) Urine Osmolarity ... Diagnosis #Algorithm #nephrology
Hyponatremia (<135 mEq/L) is a common electrolyte abnormality caused by an excess of total body water
Hyponatremia (<135 ... asymptomatic to seizures ... urea causes the hyponatremia ... True hyponatremia ... #hyponatremia #ADH
Hyponatremia - Diagnosis and Treatment
Hyponatremia is usually caused by the inability to excrete water normally.
majority of cases, ADH ... Calculate serum osmolality ... 2) Is ADH elevated ... Measure urine osmolality ... of symptomatic (seizures
Hyponatremia Diagnostic Algorithm
1) Check serum osmolality
2) Check urine osmolality
3) ADH Dependent - Check volume status, urine
Hyponatremia Diagnostic ... 1) Check serum osmolality ... 2) Check urine osmolality ... 3) ADH Dependent ... #nephrology
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
Wasting vs SIADH - Pathophysiology ... Hypovolaemia → ADH ... SaltWasting #SIADH #Pathophysiology ... #diagnosis #nephrology ... #hyponatremia #
Management of SIADH
Treat underlying cause:
 • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
Saline: • If Urine osmolality ... antagonists: • Blocks ADH ... SIADH #Management #hyponatremia ... #nephrology #treatment
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
-> Withdrawal seizure ... , asthenia • Neurologic ... vomiting, diarrhea, hyponatremia ... #SideEffects #Pathophysiology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
urea, uric acid, osmolarity ... investigations depending on clinical ... cryoglobulins, hepatitis serology ... , HIV serology, ... fragmentocytes, LDH
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
Pressure (ICP) - Pathophysiology ... Manage ICP and Seizures ... agents = increase osmolarity ... Pressure #ICP #Pathophysiology ... #neurology #neurosurgery