1117 results
Malignant Bone Tumors: Pathogenesis of X-ray appearance

 • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... metastasized to the bone ... • Metastatic bone ... cells activate osteoblasts
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... -> Reduced Bone ... Formation, Increased Bone
Bone resorption and the relationship between osteoblasts and osteoclasts.  
RANK is expressed on the osteoclasts,
Bone resorption ... relationship between osteoblasts ... marrow cells and osteoblasts ... the surface of bone ... Endocrinology #Osteoblasts
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
cartilaginous matrix by osteoblasts ... forms bony callus ... • Osteoclast-osteoblast ... coupled bone remodeling ... from GI tract, bone
Hypocalcemia Workup - Differential Diagnosis Algorithm
 • Low Magnesium, High Magnesium - Functional Hypoparathyroidism
 • High
Pancreatitis, Sepsis, Osteoblastic ... metastases, Hungry bone
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
Postparathyroidectomy (hungry bone ... syndrome) - Osteoblastic ... metastasis (hungry bone
Causes of Hypomagnesemia
 • Redistribution: IV glucose, Correction of diabetic ketoacidosis, IV hyperalimentation, Refeeding after starvation,
Postparathyroidectomy (hungry bone ... syndrome), Osteoblastic ... metastasis (hungry bone
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... IGFIR activates osteoblasts
Tracheobronchopathia Osteochondroplastica (TPO) on Bronchoscopy

Tracheobronchopathia osteochondroplastica (TBPOCP) is an uncommon benign condition affecting the lumen of
tracheopathia osteoplastica ... proliferation of bone
Tracheobronchopathia Osteochondroplastica (TPO) on Bronchoscopy

Tracheobronchopathia osteochondroplastica (TBPOCP) is an uncommon benign condition affecting the lumen of
tracheopathia osteoplastica ... proliferation of bone