113 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... hemophagocytosis and cytokine overproduction ... MAS #Macrophage #Activation
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
hemianopsia IGF-1 Overproduction ... GrowthHormone #GH #Excess #Overproduction
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
anaphylaxis is mast cell activation ... Inappropriate mast cell activation ... cells • ANS activation
The parasympathetic and sympathetic systems - Activation and inhibition pathways by organ system

#Sympathetic #Parasympathetic #Systems #Pathways
sympathetic systems - Activation
Fibrinolysis. 
Fibrinolysis occurs when plasminogen is activated to plasmin under the influence of factors such as
tissue plasminogen activator ... thrornbolytic drugs by activating
Transplant Infections Timeline
Pre-transplant:
 • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut)
 • Viruses: HSV (reactivation)
Engraftment:
Viruses: HSV (reactivation ... Viruses: HSV (reactivation ... Viruses: CMV (reactivation ... ), VZV (reactivation ... ), CMV (reactivation
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Inhibits plasminogen activation ... reduces complement activation
Calcium Channel Blocker Conversion Table

Nifedipine versus amlodipine - Nifedipine XL used only as the short acting
associated with activation
Three Ds of Clinical Debriefing : Deactivation, Deconstruction and Dissemination 

- Dr. Ben Symon https://twitter.com/symon_ben

#Clinical #Debriefing
Clinical Debriefing : Deactivation ... Debriefing #3Ds #DDDs #Deactivation
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Complement Pathway Activation