29 results
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Elevated Globulin ... of an Elevated Globulin ... • An elevated globulin ... increase in the globulin ... ratio indicates overproduction
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transthyretin) Albumin Globulins ... Corticosteroid-binding globulin
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
hemianopsia IGF-1 Overproduction ... GrowthHormone #GH #Excess #Overproduction
Hirsutism & Virilization - Differential Diagnosis Algorithm
ADRENAL EXCESS
Ovarian
 • Polycystic Ovarian Syndrome
 • Hyperthecosis
 • Tumor
Adrenal
Hormone Binding Globulin
Adrenal Insufficiency Diagnosis Algorithm
Test 1: Baseline AM Cortisol 
 - Beware of major normal value
 -
elevated in high globulin
Immunosuppression in Transplantation
Induction (I):
 - Basiliximab (Simulect)
 - Alemtuzumab (Campath)
 - Rituximab
 - Anti-Thymocyte Globulin (ATG)
Induction
Anti-Thymocyte Globulin
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
(antithymocyte globulin
Causes of Nephrolithiasis - Differential Diagnosis Algorithm
Radio-opaque - Calcium-containing - 90% of stones
Radiolucent - Non-calcium 10%
Hyperoxaluria: • Enteric overproduction
Pathology - Hepatocyte Pigments

Lipofuschin (H&E) 

Alpha-I-antitrypsin globules (PAS-D) 

Mallory's hyaline / Mallory Denk Bodies 

Giant Mitochondria
Alpha-I-antitrypsin globules
Important Cardiac Transplant Medications and Side Effects
 • Cyclosporine (Sandimmune, generic) - Calcineurin inhibitor, decreasing T
antithymocyte gamma-globulin