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diagnosis endocrinology differential gh hematology management pathophysiology signs symptoms syndrome activation algorithm causes cushings excess feedbackloop function gap globulin hepatology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
hemianopsia IGF-1 Overproduction ... fraction • HTN #GrowthHormone ... #GH #Excess #Overproduction
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
metabolic abn #GrowthHormone
Causes of Nephrolithiasis - Differential Diagnosis Algorithm Radio-opaque - Calcium-containing - 90% of stones Radiolucent - Non-calcium 10%
Hyperoxaluria: • Enteric overproduction
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Unconjugated) - Overproduction
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features 1) Skin • Thin, easily bruisable skin with
skin due to an overproduction
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
hemophagocytosis and cytokine overproduction
Pheochromocytoma - Diagnosis and Management Summary 10 percent rule = 10% of pheochromocytomas are extra-adrenal, multiple, bilateral,
erythrocytosis due to overproduction
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
ratio indicates overproduction
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