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hematology oncology aplastic myelodysplastic chronic encephalopathy erythematosus globulin lupus lymphocytic myelodysplasia neurology platelets posterior pres protein proteingap reversible rheumatology sle
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... APML, CLL Acute ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... leukemia Management ... Myelodysplastic #Syndrome ... #MDS #Diagnosis ... #Management #treatment
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
(transfusions, antibiotics ... Can progress to MDS ... or acute leukemia ... #diagnosis #management ... #treatment #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
- Summary Cancer ... • Neutropenia, anemia ... • Richter’s Syndrome ... ’s lymphoma or acute ... syndrome • Smoldering
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... #Diagnosis #Algorithm
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... myelodysplastic syndrome ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Cell Leukemia ... isoniazid) • Antibiotics ... blood count with differential ... #diagnosis #hematology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Encephalopathy Syndrome ... Clinico-Radiological Syndrome ... the neurologic syndrome ... Paraneoplastic syndrome ... #diagnosis #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... ovarian tumors, lung cancers ... anemia • Other ... #ProteinGap #differential ... #diagnosis #hematology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic syndromes ... Myelodysplastic syndromes ... clonal evolution to acute ... myeloid leukemia ... #algorithm #hematology
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