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hematology oncology differential management algorithm myelodysplastic cancer cardiology chronic cll endocarditis infectiousdiseases lymphocytic myelodysplasia secondary workup
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... bleeding from low platelets ... Can progress to MDS ... or acute leukemia ... #Anemia #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... ): • Acute infection ... malignancies • Anemia ... Myelodysplastic syndrome ... #Causes #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... (MD) - Diagnosis ... leukemia Management ... Myelodysplastic #Syndrome ... #MDS #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... anemia Treatment ... #hematology #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Elevated Platelet ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... Matthew Ho, MD
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Myelodysplastic syndromes ... • Anemia • Aplastic ... isoniazid) • Antibiotics ... #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... Pure red cell aplasia ... • Richter’s Syndrome ... ’s lymphoma or acute ... • Sezary syndrome
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic syndromes ... Myelodysplastic syndromes ... clonal evolution to acute ... myeloid leukemia ... median age at diagnosis
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Endocarditis - Overview ... Culture Positive: • Acute ... Cholesterol emboli syndrome ... Leukocytosis, anemia ... • IV antibiotics
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