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diagnosis hematology anemia chronic leukemia lymphocytic mds myelodysplastic apml classification differentiation hemeonc hemophagocytic hlh hodgkins lymphohistiocytosis lymphoma myelodysplasia syndromes workup
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
: • Recurrent infections ... (transfusions, antibiotics ... if neutropenic fever ... Anemia #diagnosis #management ... #treatment #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- Overview Who ... - β-lactam antibiotics ... anemia Treatment ... #Anemia #oncology ... #management
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... risk-stratification • Risks: infection ... Allogeneic stem cell ... #treatment #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... weeks without infection ... aplasia • ITP ... microglobulin Treatment ... diagnosis #workup #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... following: • Fever ... rapidly, and empiric antibiotic ... #treatment #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
) - Summary Overview ... ) B symptoms → fevers ... Complications: 1) Infection ... Lymphocytic #Leukemia #oncology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
petechiae) • Frequent infections ... Causes • Anemia • Aplastic ... isoniazid) • Antibiotics ... • Parvovirus infection ... #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Subacute-Acute: • Common: fever ... Differential Diagnosis: Infection ... APML #diagnosis #management ... #hematology #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin's Lymphoma Overview ... History of EBV infection ... • Dyspnea • Fever ... Hodgkin Lymphoma Treatment ... #oncology #management
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