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hematology anemia chronic cll leukemia lymphocytic mds myelodysplastic apml classification differentiation febrile hemeonc hemophagocytic hlh hodgkins infant lp lymphohistiocytosis lymphoma
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- Overview Who ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis ... #management
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
: • Recurrent infections ... (transfusions, antibiotics ... if neutropenic fever ... #management #treatment ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... risk-stratification • Risks: infection ... #Management #treatment ... #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... following: • Fever ... rapidly, and empiric antibiotic ... #management #treatment
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... serious bacterial infections ... #Management #Pediatrics ... #Peds #Febrile ... #LP #Antibiotics
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
CLL) - Summary Overview ... ) B symptoms → fevers ... Complications: 1) Infection ... Lymphocytic #Leukemia #oncology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis ... #Management #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Subacute-Acute: • Common: fever ... : Infection (sepsis ... #management #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... weeks without infection ... Pure red cell aplasia ... microglobulin Treatment ... #workup #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Causes • Anemia • Aplastic ... isoniazid) • Antibiotics ... • Parvovirus infection ... #diagnosis #hematology ... #oncology
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