12 results
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Investigation of Abnormal Coagulation ... PT - Prolonged aPTT ... #Algorithm #Coagulation ... #Laboratory #Hematology ... #Diagnosis #Workup
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
(DIC) Overview ... venipuncture sites Laboratory ... INR < 2.3 - APTT ... #diagnosis #causes ... treatment #management #hematology
Learning about thromboelastography (TEG).
- Tom Fadial
@thame

#Diagnosis #Hematology #Coagulation #Pharmacology #Thromboelastogram #TEG #Interpretation #Thromboelastography #Laboratory
Fadial @thame #Diagnosis ... #Hematology #Coagulation ... #Pharmacology # ... Thromboelastography #Laboratory
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
(DIC) Platelet ... aggregation PT, aPTT ... small vessels #DIC ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Thromboplastin Time (PTT ... Thromboplastin Time (PTT ... elevated in: • DIC ... Thromboplastin #laboratory ... #hematology #diagnosis
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
intravascular coagulation ... (DIC) c. ... Prolonged #Causes #diagnosis ... #differential #hematology ... #coagulation
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... malnutrition, Antibiotics ... Post-partum • Acute DIC ... table #comparison #diagnosis ... #hematology #deficiency
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... intravascularcoagulation (DIC ... Prolonged #Causes #diagnosis ... #differential #hematology ... #coagulation
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... and laboratory ... diagnosis, not a ... intravascular coagulation ... hemolytic #anemia #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... intravascular coagulation ... (DIC) - HELLP ... Drugs (Beta lactam antibiotics ... #hematology #anemia